Apex Scientific

21+ access.
Research use only.

Before entering, confirm that you meet the age requirement and understand the research-use limitations that apply to every Apex product.

If provided, your email can be carried into checkout for convenience. It is not required to browse and does not subscribe you to marketing. Read the Privacy Notice, Research Use Policy, and Terms.

Leave site

Your acknowledgement is remembered on this device for 30 days.

Research use only Clear product information Free shipping on orders over $200 20% launch offer · Use code APEX101
Apex Scientific
SearchBag

Compound guide

5-AMINO-1MQ

A pathway-focused guide to molecular mechanisms, published evidence, and the limits of interpretation.

Overview

A Summary:5-AMINO-1MQ

5-Amino-1MQ is a small-molecule inhibitor used to study nicotinamide N-methyltransferase (NNMT), an enzyme involved in nicotinamide and methyl-donor metabolism.

NNMT inhibition is investigated for effects on NAD-related metabolism, methylation balance, adipocyte biology, glucose handling, and liver-metabolism models.

Published outcome data are predominantly preclinical, including diet-induced obesity models in mice. Human benefits and long-term safety have not been established.

Research model

Cellular & MolecularHow 5-AMINO-1MQ Is Studied

These receptors, enzymes, and signaling networks define the primary laboratory questions associated with this research material.

01Nicotinamide methylation

NNMT enzyme

At the cellular or molecular level

NNMT transfers a methyl group from S-adenosylmethionine to nicotinamide. 5-Amino-1MQ inhibits that enzyme in experimental systems, reducing formation of methylated nicotinamide products.

02Energy cofactor availability

NAD precursor balance

At the cellular or molecular level

Because nicotinamide can be recycled into NAD+, reducing one route of nicotinamide disposal could alter the precursor pool available for NAD-related metabolism. The actual effect depends on many competing enzymes.

03Fat-cell energy use

Adipocyte metabolism

At the cellular or molecular level

Mouse and cell studies associate NNMT inhibition with changes in adipose energy expenditure, methyl-donor balance, and metabolic gene activity.

Research interpretation

How to read the pathway.

01

Nicotinamide methylation

NNMT transfers a methyl group from S-adenosylmethionine to nicotinamide.

02

Energy cofactor availability

Because nicotinamide can be recycled into NAD+, reducing one route of nicotinamide disposal could alter the precursor pool available for NAD-related metabolism.

03

Fat-cell energy use

Mouse and cell studies associate NNMT inhibition with changes in adipose energy expenditure, methyl-donor balance, and metabolic gene activity.

Evidence boundary

Published outcome data are predominantly preclinical, including diet-induced obesity models in mice. Human benefits and long-term safety have not been established.

Read the evidence

Sources BehindThis Guide

5-Amino-1MQ metabolic research in mice (opens in a new tab)5-amino-1-methylquinolinium identity record (opens in a new tab)

One important note

Educational Notice

Published intervention findings are from laboratory and animal models, including mouse studies of diet-related obesity and metabolic function. Controlled human outcome data are not established.

This guide summarizes molecular mechanisms, published evidence, and evidence limits in everyday language. It is educational information, not medical advice or instructions for personal use. Products offered on this site are intended exclusively for laboratory research and are not for human or veterinary use.